The answer isn't that 81 mg is magically more effective than 80 mg. Instead, it comes from the historical conversion of 5 grains (an old apothecary unit) into the metric system, which equals about 324 mg.
One-quarter of that dose became 81 mg, and the strength remained the standard for low-dose aspirin.
Sometimes, medicine isn't just about pharmacology… It's also about history.
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